Self-emulsifying drug delivery systems (SEDDS), composed of drugs, oil phases, surfactants and cosurfactants, can spontaneously form sub 500 nm oil-in-water emulsions in the gastrointestinal tract to enhance the oral bioavailability of poorly water-soluble drugs. This review summarizes SEDDS’ latest research progress: It outlines prescription optimization methods (e.g., pseudo-ternary phase diagram, response surface methodology), covers quality evaluation indexes (particle size, zeta potential) and drug release studies, and introduces novel formulations like solid self-microemulsions and supersaturated self-microemulsions that address traditional SEDDS’ limitations. Future directions include developing low toxicity natural excipients and achieving targeted release, providing references for SEDDS’ research and industrialization.
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Wu, T. (2025) Research Progress on Formulation Optimization, Quality Evaluation, and Novel Formulation Technologies of Selfemulsifying Drug Delivery Systems. Scientific Research Bulletin, 2(3), 8-21.