Carbon monoxide (CO), a pervasive environmental toxicant, has emerged as one of the leading causes of fatal poisoning. In the short term, inhalation of excessive amounts of this gas can lead to a systemic illness, primarily affecting the central nervous system, known as acute carbon monoxide poisoning (ACMP). Despite numerous hypotheses proposed by scholars – such as the apoptosis and autophagy theories, ischemia-reperfusion injury and free radical hypotheses, and the excitatory amino acid hypothesis – the precise mechanisms of action remain inadequately elucidated. Consequently, the primary aim of this study is to outline recent research into focal areas and elucidate the critical role of microglial pyroptosis in the molecular mechanisms underlying ACMP. It is anticipated that this will provide a theoretical foundation for a deeper understanding of the pathological mechanisms of ACMP and the exploration of novel therapeutic drug targets.
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Li, M., Yang, J., Wang, L., Xue, H., Zhao, X., Wang, Y., Huang, T., Jiang, M., Ren, X., Xia, Y., Gao, M., Deng, X., Yuan, Y., Liu, S., He, Y., Zhang, S. (2025) Explore the Advancements in Research on Pyroptosis of Microglial Cells in Acute Carbon Monoxide Poisoning. Journal of Disease and Public Health, 1(2), 75-84. https://doi.org/10.71052/jdph/STQJ7584