Self-healing hydrogels are a type of hydrogel capable of autonomously repairing damage or restoring their integrity after being damaged. This property equips hydrogels with enhanced mechanical properties, superior biocompatibility, and additional biological and environmental functions. Polysaccharides, due to their excellent biodegradability and biosafety, have become ideal matrix materials for self-healing hydrogels. The self-healing polysaccharide hydrogels formed by incorporating polysaccharides can generate dynamic and reversible interactions through the hydrophilic and hydrophobic functional groups abundant on polysaccharide molecular chains, thereby enhancing the self-healing ability of the hydrogels. This article reviews the research progress of polysaccharide self-healing hydrogels from aspects of self-healing mechanisms, material selection, and applications in biomedicine, wearable devices, and ion adsorption.
References
[1] White, S. R., Sottos, N. R., Geubelle, P. H., Moore, J. S., Kessler, M. R., Sriram, S. R., Brown, E. N., Viswanathan, S. (2001) Autonomic healing of polymer composites. Nature, 409(6822), 794-797.
[2] Zhang, M., Chen, Y. M., Wang, D., et al. (2021) Research Progress on Stimuli-Responsive Self-Healing Hydrogels. Progress in Chemistry, 33(4), 565-579.
[3] Liu, Y., Zhang, Z. P., Sun, Y. (2020) Preparation and Applications of Polysaccharide-Based Self-Healing Hydrogels. Acta Polymerica Sinica, 51(10), 1173-1190.
[4] Yin, D. L., Ma, G. P., Ni, S. L. (2022) Preparation of Cellulose/Chitosan-Based SelfHealing Hydrogels and Their Applications in Biomedical Field. Materials Reports, 36(15), 21030063.
[5] Song, X. L., Zhang, N., Wang, H. Y., et al. (2021) Classification of Self-Healing Hydrogels and Their Research Progress in Biomedical Applications. Materials Reports, 35(21), 21140-21148.
[6] Wang, L., Zhang, L., Liu, P., et al. (2019) Preparation and Self-Healing Properties of Cationic Guar Gum/Copper Ion Composite Hydrogels. Polymer Materials Science and Engineering, 35(8), 72-78.
[7] Zhao, J., Chen, W., Sun, H. W., et al. (2020) Preparation and Properties of pH-Responsive Polyacrylic Acid Self-Healing Hydrogels. Journal of Functional Materials, 51(11), 11070-11075.
[8] Chen, C., Li, Z., Chen, S., Kong, L., Guo, Z., Hu, J., Yang, L. (2021) The preparation of hydrogels with highly efficient self-healing and excellent mechanical properties. Journal of Molecular Liquids, 329, 115581.
[9] Li, Z. Q., Wang, J., Zhang, H., et al. (2019) Preparation and Properties of N, NDimethylacrylamide Hydrogels Based on Hydrophobic Association. Acta Polymerica Sinica, (5), 489-497.
[10] Xu, M., Liu, W., Chen, Y. M., et al. (2020) Preparation and Self-Healing Properties of Supramolecular Hydrogels Based on Cyclodextrin-Glycyrrhetinic Acid Host-Guest Recognition. Acta Chimica Sinica, 78(10), 1070-1078.
[11] Song, C. J., Wang, F., Fang, Y. P., et al. (2020) Preparation and Performance Characterization of Banana Cellulose/Chitosan-Polyacrylamide Double-Network Hydrogels. Food Science, 41(24), 82-89.
[12] Li, Z. Y., Liu, R. L., Hu, J. P., et al. (2021) Preparation and Self-Healing Properties of Zn²⁺ Coordination-Enhanced Polyacrylamide/Chitin Nanowhisker Composite Hydrogels. Acta Materiae Compositae Sinica, 38(6), 1922-1931.
[13] Swati G., Wang, J., Li, N., et al. (2021) Preparation and Self-Healing Properties of Chitosan-Crotonaldehyde-Based Dynamic Imine Bond Hydrogels. Polymer Materials Science and Engineering, 37(3), 45-52.
[14] Jiang, C., Liu, W. J., Zhang, L., et al. (2022) Construction of pH-Responsive Cellulose Hydrogels Based on Hydrazone Bonds and Cyclodextrin Host-Guest Interactions. Acta Chimica Sinica, 80(5), 610-618.
[15] Yang, X. M., Chen, Z. Q., Zhao, W. W., et al. (2020) Preparation and Properties of Carbon Nanotube/Polyethylene Glycol Self-Healing Nanocomposite Hydrogels Based on DielsAlder Reaction. Acta Materiae Compositae Sinica, 37(9), 2145-2153.
[16] Guo, R., Su, Q., Zhang, J., Dong, A., Lin, C., Zhang, J. (2017) Facile Access to Multisensitive and Self-Healing Hydrogels with Reversible and Dynamic Boronic Ester and Disulfide Linkages. Biomacromolecules, 18(4), 1356-1364.
[17] Liu, R. L., Hu, J. P., Li, Y. J., et al. (2021) Preparation, Functionalization and Application Progress of Natural Polysaccharide-Based Hydrogels. Materials Reports, 35(15), 1507315086.
[18] Zhang, N., Wang, H. Y., Song, X. L. (2022) Construction Strategies and Performance Research Progress of Polysaccharide/Synthetic Polymer Composite Hydrogels. Acta Polymerica Sinica, 53(2), 147-161.
[19] Wang, Q. Q., Zhang, Y., Liu, H. B. (2020) Characteristics of Polyethylene Glycol and Its Research Progress in Biomedical Applications. Chinese Journal of Biomedical Engineering, 39(4), 477-485.
[20] Chen, Q., Li, J. J., Sun, H., et al. (2021) Preparation and Reinforcement Mechanism of Polyvinyl Alcohol/Cellulose Nanocrystal Composite Hydrogels. Acta Materiae Compositae Sinica, 38(7), 2282-2291.
[21] Xu, M., Zhao, J., Gao, Z. Q., et al. (2019) Preparation and Properties of Polyvinylpyrrolidone/Chitosan-Based SelfHealing Hydrogel Films. Journal of Functional Materials, 50(11), 11068-11074.
[22] Liu, Y., Zhang, Z. P, Sun, Y. (2022) Reinforcement and Toughening Mechanisms and Applications of Polyurethane/Polysaccharide Composite Hydrogels. Polymer Bulletin, (5), 1-12.
[23] Li, M., Wang, F., Xie, Q. L., et al. (2021) Preparation and Properties of High-Strength Self-Healing Polyurethane/Sodium Alginate Composite Hydrogels. Chemical Industry and Engineering Progress, 40(3), 1450-1458.
[24] Zhao, J., Chen, W., Sun, H. W., et al. (2020) Preparation and Properties of pH-Responsive Polyacrylic Acid Self-Healing Hydrogels. Journal of Functional Materials, 51(11), 11070-11075.
[25] Guo, Z. Y., Tang, S. J., Zhang, Z. Y., et al. (2025) Research Progress on Self-Healing Hydrogels and Their Flexible Sensors. New Chemical Materials, 53(09), 64-69.
[26] Nie, J. D., Huang, J. R., Fan, J. F., et al. (2020) Strengthened, Self-Healing, and Conductive ENR-Based Composites Based on Multiple Hydrogen Bonding Interactions. ACS Sustainable Chemistry & Engineering, 8(36), 13724-13733.
[27] Li, W., Zhang, M., Wang, L., et al. (2020) Research Progress and Prospect of Heavy Metal Wastewater Treatment Technologies. Chinese Journal of Environmental Engineering, 14(5), 1085-1098.
[28] Hou, Q. W., Liu, R. L., Hu, J. P., et al. (2021) Preparation of Sodium Alginate/Seaweed Polysaccharide Calcium-Cross-Linked Hydrogel Beads and Their Adsorption Properties for Cu²⁺ and Pb²⁺. Acta Scientiae Circumstantiae, 41(8), 3120-3129.
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Huang, W. (2025) Research Progress on Self-Healing Polysaccharide Hydrogels. Scientific Research Bulletin, 2(1), 33-43.