Objective: To evaluate the clinical efficacy and safety of Guizhi Fuling Decoction combined with metronidazole in patients with chronic endometritis. Methods: A total of 100 women with histopathologically and immunohistochemically confirmed chronic endometritis were enrolled between January 2020 and October 2022. All participants were treated at the Department of Reproductive Medicine, the Second Affiliated Hospital of Xingtai Medical College, and randomly allocated to an experimental group or a control group (n=50 per group). Results: Both groups showed improvement after treatment. However, the experimental group demonstrated significantly greater increases in endometrial thickness and blood flow scores, accompanied by more pronounced improvement in pathological findings compared with the control group (P<0.05). In addition, key immunohistochemical markers associated with chronic inflammation showed a substantial reduction in the experimental group, indicating stronger suppression of endometrial inflammatory activity. The clinical pregnancy rate was significantly higher in the experimental group than in the control group (50.00% vs. 24.00%, P<0.05). The overall incidence of adverse reactions was lower in the experimental group (12.00%) compared with the control group (22.00%) (P=0.048). Conclusion: Guizhi Fuling Decoction combined with metronidazole effectively improves endometrial morphology, blood flow, inflammatory status, and clinical pregnancy outcomes, while demonstrating a favorable safety profile. This combined regimen represents a promising and safe therapeutic approach for patients with chronic endometritis.
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Yang, X. (2025) Clinical Efficacy and Immunohistochemical Changes Following Guizhi Fuling Decoction Combined with Metronidazole in the Treatment of Chronic Endometritis. Journal of Disease and Public Health, 1(1), 66-73. https://doi.org/10.71052/jdph/HZWN5169